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The aging gut faces multiple challenges: Reduced bacterial diversity - fewer species means less metabolic flexibility Decreased butyrate producers - particularly Faecalibacterium prausnitzii and Roseburia species Slower transit time - affecting fermentation patterns Changes in digestive secretions - impacting bacterial growth conditions Medication effects - many common medications affect gut bacteria These changes create a cycle where reduced butyrate production may be linked with increased intestinal permeability, low-grade inflammation, and further microbiome changes

However, human biology differs significantly

References 1.Sato Y., Yanagita M

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